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Wednesday, October 7, 2020 | History

2 edition of Mucociliary clearance and asthma found in the catalog.

Mucociliary clearance and asthma

Thomas G. O"Riordan

Mucociliary clearance and asthma

the relevance of mucociliary clearance measurements to clinical asthma

by Thomas G. O"Riordan

  • 51 Want to read
  • 13 Currently reading

Published .
Written in English


Edition Notes

Thesis (M.D.) - University College Dublin, National University of Ireland, 1993.

StatementThomas G. O"Riordan.
ID Numbers
Open LibraryOL20222686M

  Mucociliary clearance (MCC) is an integral part of lung defense mechanisms, enabling efficient clearance of inhaled particles, including microorganisms, from the respiratory tract [1, 2].Airway infections and ciliary dysfunctions can lead to impaired mucus transport [3, 4] and can thereby enhance the fraction of retained particles, including microorganisms in the by: The degree of airway inflammation is directly related to asthma severity and associated hyper-responsiveness. Airway inflammation is categorized into three types: (a) acute asthmatic inflammation featured by early recruitment of cells into the airways, (b) subacute asthmatic inflammation involving activation of recruited cells in continual inflammation, and (c) chronic inflammation Author: Poonam Arora, S.H. Ansari.

  BACKGROUND: Exposure to cigarette smoke causes significant impairment in mucociliary clearance (MCC), which predisposes patients to secretion retention and recurrent airway infections that play a role in exacerbations of COPD. To determine whether smoking cessation may influence MCC and frequency of exacerbations, the following groups were evaluated: ex-smokers with . mucociliary clearance and, Air pollution book review Air, the environment, and public health (Kessel AS), 70 Airway clearance. See Mucociliary clearance A irway obstruction airway stents for respiratory failure from central airway collapse, congenital, mucociliary clearance in children with, endotracheal cuff deflation in high.

  Maurizio Vignola was a superb and innovative researcher, who wrote seminal papers on the biology of airway epithelium in asthma. Inflammation and remodelling were the main topics of his research, mostly conducted in biopsy specimens from patients with asthma of variable severity, encompassing the entire spectrum of the disease from mild to severe by: 9.   Drugs acting on respiratory system RESPIRATORY DISEASES Asthma Allergic rhinitis Chronic obstructive pulmonary disease Cough 3. these effects may enhance mucociliary clearance, and thereby reverse the defective clearance found in asthma.


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Mucociliary clearance and asthma by Thomas G. O"Riordan Download PDF EPUB FB2

Duncan F. Rogers, in Asthma and COPD (Second Edition), Asthma. Airway mucociliary clearance is well documented as being impaired in asthma [72]. Clearance is impaired even in patients in remission [81] and in those with mild stable disease [82].

Mucus clearance is proportionally reduced in symptomatic asthmatics [83] and during. Mucociliary clearance (MCC), mucociliary transport, or the mucociliary escalator, describes the self-clearing mechanism of the airways in the respiratory system. It is one of the two protective processes for the lungs in removing inhaled particles including pathogens before they can reach the delicate tissue of the lungs.

The other clearance mechanism is provided by the cough : D Mucociliary Clearance in Asthma and COPD Clearance of mucus from the airways is impaired in patients with a variety of respiratory diseases, including asthma and COPD [73]. However, it should be noted that there are often discrepancies in results between studies that are invariably due to differences in methodology [74, 75], but may also be.

Mucociliary clearance (MCC) is one of the most important nonspecific defense mechanisms of the respiratory tract, and its impairment is a well-documented feature of chronic respiratory diseases, including asthma.

In vitro and in vivo data suggest that several inflammatory mediators influence the mucociliary apparatus. Mucociliary clearance (MCC) is one of the most importantnonspecific defense mechanisms of the respiratory tract, and itsimpairment is a well-documented feature of chronic respiratorydiseases, including asthma.

In vitro and in vivo data suggest that severalinflammatory mediators influence the mucociliary apparatus. Epithelialdamage and functional abnormalities have been described in Cited by: Tracheobronchial mucociliary clearance was measured in eight non-smoking patients with asthma in complete remission.

The Mucociliary clearance and asthma book were symptom free and required no medication whatsoever for one to six months before assessment. Mucociliary clearance Cited by: The effect of inflammation on mucociliary clearance asthma: An overview Article Literature Review (PDF Available) in Chest (4) November with 53 Reads How we measure 'reads'.

Upper respiratory tract viral infection and mucociliary clearance. Wilson R, Alton E, Rutman A, Higgins P, Al Nakib W, Geddes DM, Tyrrell DA, Cole PJ. Twenty-six normal volunteers were exposed to rhinovirus or influenza B by: Airway mucus is a viscoelastic gel containing water, carbohydrates, proteins, and lipids.

It is the secretory product of the mucous cells (the goblet cells of the airway surface epithelium and the submucosal glands). Mucus is transported from the lower respiratory tract into the pharynx by. "Mucociliary clearance in the airways." American journal of respiratory and critical care medicine, (6), pp.

–Cited by: Lung mucociliary clearance rates are reduced during sleep in patients with asthma. Methylxanthines and beta 2 agonists have been shown to enhance rates of lung mucociliary clearance. Asthma affects approximately million people worldwide and causes approximatelydeaths annually ().Tracheobronchial mucociliary clearance is impaired in stable asthma and worsens during acute exacerbations ().The principal cause of death from asthma is asphyxiation from intraluminal airway obstruction by widespread mucus plugs (4 – 6).

Isawa T, Teshima T, Hirano T, Ebina A, Konno K () Mucociliary clearance mechanism in interstitial lung disease. Tohoku J Exp Med – PubMed CrossRef Google Scholar mucociliary clearance: the movement of the mucous covering of the respiratory epithelium by the beating of cilia: rapid, forward (effective) stroke and slow, return (recovery) stroke.

In the nose, mucus is moved toward the pharynx. In the tracheobronchial tree, mucus is moved toward and through the larynx and swallowed. Synonym(s): mucociliary.

mucociliary clearance. In established disease, there is a vicious cycle of inflammation driven by neutrophils, recurrent or persistent infection, primarily with Haemophilus influenzae and injury to epithelium and bronchial and bronchiolar structures (figure 2).

The anatomical damage further impairs mucociliary clearance. Introduction. Pneumonia is the leading infectious cause of death in the elderly. Impaired respiratory defences are one of the causes for increased susceptibility of the elderly to such infections.

Nasal mucociliary clearance, the mirror image of bronchial clearance, is crucial in respiratory defence and is affected by various by: 6. Reserve your copy now. This two volume book is an outstanding reference source on all aspects of allergy and allergic diseases.

Covering virtually every allergic condition, from the immunological and molecular basis of the allergic response to future trends in allergic disease prevention, this new international editorial team (, Jean Bousquet, Pat Holt and Allen Kaplan) have.

The objective of this study was to investigate whether reduced bronchial mucus transport velocity (BTV) is associated with a loss of cilia or ultrastructural abnormalities of cilia in intubated patients. The patients were studied prospectively in a convenience sample trial.

The study took place in a university hospital. 29 orally intubated patients in a surgical by: A theoretical model of the movement of aerosols in the lungs is proposed. The model is based upon the transport equations taking into account the aerosol inertial deposition processes.

Particles move along curvilinear trajectories in self-twisted vortex air flows. Deposition occurs over several cycles of inhalation and exhalation.

This mechanism works for particles with a diameter greater than Author: Gennady Fedorovitch. Invited Review Mucociliary and Cough Clearance as a Biomarker for Therapeutic Development William D. Bennett, Ph.D.,1 Evangelia Daviskas, Ph.D.,2 Amir Hasani Ph.D.,3 Jann Mortensen, M.D.,4 John Fleming Ph.D.,5 and Gerhard Scheuch, Ph.D.6 Abstract A workshop/symposium on ‘‘Mucociliary and Cough Clearance (MCC/CC) as a Biomarker for Therapeutic.

Normal Clearance. Normal airway clearance requires a patent airway, a functional mucociliary escalator, and an effective cough. 5,19,20 Airways normally are kept open by structural support mechanisms (see Chapter 8) and kept clear by proper function of the ciliated mucociliary clearance mechanism operates from the larynx down to the respiratory bronchioles.2.

The multiscale mechanics of mucociliary transport in the human airways. MCC is powered by an estimated 2 × 10 12 motile cilia that propel a layer of mucus towards the larynx [3,4].Healthy airway epithelia contain mostly multiciliated cells and are covered with an airway surface liquid (ASL) consisting of two components, a mucus layer near the tip of the cilia that is propelled by the Cited by: 1.People with asthma and GER (9% of asthmatics had GER) had more nocturnal cough and morning phlegm with sleep-related symptoms.

9 The authors concluded that there was a strong association between asthma and GER. Cigarette smoking is known to stop mucociliary clearance.